DEVELOPMENT AND CHARACTERIZATION OF VITAMIN B9 - ELECTROSPRAYED NON-WOVEN SURFACES FOR WOUND HEALING APPLICATIONS

Authors : Fatma Nur PARIN, Kenan YILDIRIM, Gökçe TANER, Elife KILDALI

Pages : 70-84

Doi:10.18038/estubtda.983329

View : 27 | Download : 10

Publication Date : 2021-11-30

Article Type : Research Paper

Abstract :In this study, novel wound dressing materials based on non-woven insert ignore into journalissuearticles values(NW); surfaces were developed using electrospraying insert ignore into journalissuearticles values(e-spraying); process. Polyester spunbond insert ignore into journalissuearticles values(PET SPB);, polypropylene spunbond insert ignore into journalissuearticles values(PP SPB);, and polypropylene melt-blown insert ignore into journalissuearticles values(PP MB); surfaces used as matrix, and folic acid insert ignore into journalissuearticles values(FA);, vitamin B9 were sprayed on these surfaces. The resulting NW fabrics with the same FA content were investigated in terms of chemical, morphological, thermal, wettability properties. Scanning Electron Microscopy and insert ignore into journalissuearticles values(SEM); and Fourier Transform Infrared insert ignore into journalissuearticles values(FT-IR); spectroscopy results showed formation of physical interaction between NWs and FA is successfully deposited onto NWs with average fiber diameters from 2.6 µm to 23.11 µm. According to the thermogravimetric analysis insert ignore into journalissuearticles values(TGA); FA loaded-PP SPB have enhaced thermal stability compared to pure one insert ignore into journalissuearticles values(PP SPB);. The FA-loaded surfaces have hydrophobic property with contact angles values more than >90°. The in-vitro release was carried out by UV-Vis within the 8 hour-period phosphate buffer saline insert ignore into journalissuearticles values(pH 7.2);. The results indicated that FA-loaded surfaces have a fast release behaviour. The total FA release amounts of the FA-loaded PET SBP, PP SPB and PP MB NWs were found as 22.8, 17.1, and 17.5 ppm. Moreover, biocompatibility of all resulting NW surfaces was assessed by 3-insert ignore into journalissuearticles values(4,5-dimethylthiazol-2-yl);-2,5-diphenyltetrazolium bromide insert ignore into journalissuearticles values(MTT); and neutral red uptake insert ignore into journalissuearticles values(NRU); cytotoxicity tests in L929 cell lines. The obtained NWs have biocompatible and non-toxic material except PET SPB-sFA.The study indicated that FA-loaded NWs can be potential candidates for wound healing applications.
Keywords : Non woven, wound healing, folic acid, characterization, in vitro study