Inflammatory markers and blood gas analysis in determining the severity of Chronic Obstructive Pulmonary Disease

Authors : İbrahim ÇALTEKİN, Emre GÖKÇEN, Levent ALBAYRAK, Dilek ATİK, Atakan SAVRUN, Mikail KUŞDOĞAN, Hasan KAYA, Sevilay VURAL, Şeyda Tuba SAVRUN

Pages : 187-192

View : 20 | Download : 9

Publication Date : 2020-08-26

Article Type : Research Paper

Abstract :Abstract Aim: This study aimed to evaluate the severity of the disease using inflammatory markers in patients with Chronic Obstructive Pulmonary Disease insert ignore into journalissuearticles values(COPD); who admitted to the emergency department. Materials and Methods: 193 COPD patients who applied to the emergency department were included in this retrospective study. Patients were divided into two groups according to the severity of COPD. The presence of type 1 and type 2 respiratory failure was used to create Group 2 insert ignore into journalissuearticles values(severe, very severe, life-threatening); and in the absence, Group 1 insert ignore into journalissuearticles values(mild, moderate);. Inflammatory markers such as Neutrophil / lymphocyte ratio insert ignore into journalissuearticles values(NLR);, Platelet / lymphocyte ratio insert ignore into journalissuearticles values(PLR);, Lymphocyte / monocyte ratio insert ignore into journalissuearticles values(LMR); and disease severity were evaluated for both groups. Results: The high COPD severity group insert ignore into journalissuearticles values(Group 2); had higher NLR and PLR values insert ignore into journalissuearticles values(p <0.001, p <0.001, respectively);, and LMR values were lower insert ignore into journalissuearticles values(p <0.001);. There was infection in 46.2% of Group 2, while this rate was 13.5% in Group 1 insert ignore into journalissuearticles values(p <0.001);. Conclusion: As the severity of the disease increases, NLR, PLR values increase, and LMR value decreases. This indicates that COPD attack will be severe in the presence of infection in COPD patients.
Keywords : Blood gas analysis, emergency medicine, inflammatory markers, chronic obstructive pulmonary disease COPD,