Sesame Oil Has Gastroprotective And Anti-Oxidative Properties: An Experimental Study In Rats With Indomethacin-Induced Gastric Ulcers

Authors : Nurulhünda HANCI, Fehmi ODABASOGLU, Fadime ATALAY DUMLU, Ozlem AYDIN BERKTAŞ, Zerrin KUTLU, Mesut HALİCİ, Zekai HALİCİ

Pages : 53-68

View : 22 | Download : 10

Publication Date : 2018-12-29

Article Type : Research Paper

Abstract :Sesame oil insert ignore into journalissuearticles values(SO); is a component of the traditional health food in India as well as in oriental countries and has long been thought to possess the ability to prevent various diseases. We examined the protective effects of sesame oil against acute gastric mucosal damage induced in rats by nonsteroidal anti-inflammatory drug indomethacin insert ignore into journalissuearticles values(IND);. We also intended to determine the relation between antiulcer effect of SO and its antioxidant properties by biochemical evaluation. In this study a total of 5 rat groups were used for ulcer experiment. Antiulcer effects of SO have been investigated on 24 hour fasted 5 rat groups with indomethacine insert ignore into journalissuearticles values(IND);-induced ulcer model in the presence of positive insert ignore into journalissuearticles values(Famotidine, FAM);, negative insert ignore into journalissuearticles values(untreated IND group); and intact control groups. In ulcer experiments, two doses of SO exerted significant anti-ulcerogenic effects. In gastric tissues, sesame oil administration decreased the level of LPO and activities of CAT, GR, MPO which were increased after IND application. Furthermore, SO increased the level of GSH which decreased in ulcerous stomach tissues when compared to healthy rat group. We determined that SO has anti-ulcerative effect and this effect are related to antioxidative properties of sesame oil.
Keywords : Sesame oil, Indomethacin, Gastroprotective effect, Myeloperoxidase, Vegetable oil