The Investigation of the Effect of Topical Vascular Endothelial Growth Factor (VEGF) Administration On Serum Oxidative Parameters in Diabetic Rats

Authors : Şule COŞKUN CEVHER, Vildan SÖNMEZ ÇOBAN

Pages : 543-547

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Publication Date : 2016-09-30

Article Type : Research Paper

Abstract :There is positiveeffect of exogenvascularendothelialgrowthfactor insert ignore into journalissuearticles values(VEGF); applicationtodiabeticwound.It is aimed to research the effects of topical VEGF administration on oxidative parameters in rat serum.In this study, 36 male wistar albino rats insert ignore into journalissuearticles values(weight: 200-250 g); were used. All rats get diabetic with streptozotocin. Dorsalateral excisional wounds insert ignore into journalissuearticles values(4 cm lengthy); were made on the two sides of medulla spinalis on the rats and they were randomly divided into 3 groups: untreated groups insert ignore into journalissuearticles values(n=12);, chitosan treated insert ignore into journalissuearticles values(n=12);and chitosan+ VEGF insert ignore into journalissuearticles values(n=12);insert ignore into journalissuearticles values(7 ng/ml);. In chitosan treated groups, wounds treated topically with equal amount blank chitosan gel. After this administration on the 3 th and 7 th days of wound,animals were sacrified. NOx, TBARS and RSH levels were measured spectrophotometrically in serum. Results were expressed as mean ± standart deviation. Mean differences were compared by Anova Variance Analysisinsert ignore into journalissuearticles values(p<0,05);.  It can be thought that topical VEGF administration on the excisional wound of diabetic rats may have possitive effect on the recovery of oxidative damage in serum.
Keywords : VEGF, Diabetes mellitus, Wound Healing, Oxidative Stress, Antioxidant