Synthesis of New Ligands Containing Azomethine Group and Investigation of Antioxidant, Antiurease Activities

Authors : Nurhan GÜMRÜKÇÜOĞLU, Bahar BİLGİN SÖKMEN

Pages : 662-671

Doi:10.35378/gujs.615818

View : 27 | Download : 7

Publication Date : 2020-09-01

Article Type : Research Paper

Abstract :A series of Schiff base ligands containing 1,2,4-triazole ring were obtained by the addition of aldehydes to the amino compound under mild conditions in 80–82% yields. A reduction of these ligands with sodium borohydride resulted in Schiff base reduction products. New ligands were investigated for their antioxidant activities such as DPPH insert ignore into journalissuearticles values(2,2-diphenyl-1-picrylhydrazyl);, ABTS insert ignore into journalissuearticles values(2,2’-azino-bis insert ignore into journalissuearticles values(3-ethylbenzo-thizoline-6-sulphonic acid); diammonium salt); radical scavenging and reducing power. 1H and 13C-NMR spectra insert ignore into journalissuearticles values(δ, ppm); were observed on a Varian Mercury 200 MHz spectrophotometer as standard substance using tetramethylsilane Match constants insert ignore into journalissuearticles values(J values); were given as Hertz. NMR coefficients are truncated as follows: s=singlet, d=dublet, t=triplet, m=multiplet signal. Combustion analysis was performed on a Carlo Erba 1106 elemental analyzer. All the compounds gave C, H, and N analysis results within ±0.6 % of the theoretical values. The IR spectra insert ignore into journalissuearticles values(υ, cm−1); were viewed with a Perkin-Elmer 1600 FTIR spectrometer in KBr pellets. 
Keywords : Antioxidant activity, Azomethine group, Characterization, Ligands, Urease inhibition activity