Preparation of Poly(DL-Lactide/ε-Caprolactone)–β-TCP Composites for Bone Tissue Repair

Authors : Hasret Tolga ŞİRİN, Ebru AKDOĞAN, Erhan BİŞKİN

Pages : 133-141

View : 25 | Download : 8

Publication Date : 2019-02-01

Article Type : Research Paper

Abstract :Poly-D,L-Lactide/ε-caprolactone insert ignore into journalissuearticles values(PDLLA-ε-CL); and β-tri-calcium phosphate insert ignore into journalissuearticles values(β-TCP); composites were prepared as an alternative for injectable filling material in bone tissue repair. β-TCP was synthesized by a wet precipitation method and characterised using Fourier Transform Infrared Spectroscopy insert ignore into journalissuearticles values(FTIR);, X-Ray Diffractometer insert ignore into journalissuearticles values(XRD);, Zeta-SIZER and Brunauer–Emmett–Teller insert ignore into journalissuearticles values(BET); analyser. PDLLA-ε-CL copolymer was synthesized under nitrogen insert ignore into journalissuearticles values(N2); atmosphere using ring-opening polymerization in the presence of stannous octoate as a catalyst. The chemical structures of copolymers were determined by FTIR and Proton Nuclear Magnetic Resonance insert ignore into journalissuearticles values(1H-NMR); analysis. The average molecular weights of copolymers were identified by Gel Permeation Chromatography insert ignore into journalissuearticles values(GPC);. insert ignore into journalissuearticles values(PDLLA-ε-CL);-β-TCP composites were then prepared by loading differing amounts of β-TCP to the copolymer phase. The resulting composites were easily shaped by hand. The degradation profiles of the composites were determined by monitoring the changes in the molecular weight of the co-polymers over a period of 42 days. Degradation rate of the composites decreased as the percentage of β-TCP in the structure increased.
Keywords : Bio ceramic, tricalciumphosphate, hard tissue repair, bone filler, Poly D, L lactide ε caprolactone