Synthesis, Characterization and Biodegradation of Poly(αMethyl β-Propiolactone)

Authors : Efkan ÇATIKER, Anıl UZUNLAR

Pages : 435-443

View : 21 | Download : 10

Publication Date : 2018-09-01

Article Type : Research Paper

Abstract :Polyinsert ignore into journalissuearticles values(α-methyl β-propiolactone); insert ignore into journalissuearticles values(PmPL); was synthesized through anionic ring-opening polymerization of the corresponding lactone. Structural characterization of PmPL was performed by using FTIR, 1 H-NMR and MALDI-MS spectrometry. Thermal behavior of the polymer was investigated by using DSC and TGA. Glass transition, melting and thermal degradation temperatures of PmPL were determined as -36.7, 95.5 and 242.4 oC, respectively. Biodegradation studies were conducted at 37 oC in three different media, that is, pH 7.4 phosphate buffered saline insert ignore into journalissuearticles values(PBS);, PBS containing pancreatic trypsin and PBS containing pancreatic lipase. The biodegradation kinetics and mechanism of the polymer were followed by gravimetric measurements and LC-MS analysis. Up to 65% mass loss in 5-week period was recorded for the buffer media in the presence of lipase and trypsin. LC-MS analysis of the residues in the media revealed that biodegradation undergoes mainly through ester bond hydrolysis
Keywords : polyhydroxyalkanoates, ring opening polymerization, biodegradation, aliphatic polyesters