Synthesis of two 7,8-dioxabicyclo[4.1.1]octan-3-yl);-steroid derivatives and evaluation of their inotropic activity in an animal model.

Authors : Figueroa LAURO, Lopez MARIA, Diaz FRANCISCO, Rosas MARCELA, Mateu VIRGINIA, Garcimarrero ALEJANDRA, Borges YARITZA

Pages : 1-12

Doi:10.15671/hjbc.602029

View : 20 | Download : 8

Publication Date : 2020-04-17

Article Type : Research Paper

Abstract :The aim of this study was synthesizing two 7,8-dioxabicyclo[4.1.1]octan-3-yl); -steroid derivatives insert ignore into journalissuearticles values(compounds 3 or 4 ); to evaluate their inotropic activity in vitro . The first stage was achieved by the preparation of two 7,8-dioxabicyclo[4.1.1]octan-3-yl); -steroid derivatives using some chemical strategies. Then, the inotropic activity of both steroid derivatives against left ventricular pressure insert ignore into journalissuearticles values(LVP); was evaluated in an isolated rat heart model using Bay-k-8644, nifedipine, aucubin, and L-NAME as controls. The results showed that compound 3 increased LVP in a dose-dependent manner and this effect was inhibited by nifedipine. Other results showed that compound 4 decreased LVP in a dose-dependent manner and this effect was blocked in the presence of L-NAME. All these data indicate that 1); the positive inotropic activity exerted by compound 3 was through type L calcium channel activation; 2); the negative inotropic effect of 4 was via nitric oxide synthase activation. These phenomena could be due to the different functional groups involved in the chemical structure of compounds 3 and 4 .
Keywords : Steroid, dioxabicyclo, inotropic