Inhibitory Property of Poly (AN-co-VP) Copolymer on Some Dermatophyte Fungi and Yeasts that Cause Fungal Infections

Authors : Pınar ERECEVİT SÖNMEZ, Gülben TORĞUT, Güzin PIHTILI, Sevda KIRBAG

Pages : 313-320

Doi:10.15671/hjbc.800069

View : 27 | Download : 11

Publication Date : 2021-05-17

Article Type : Research Paper

Abstract :In recent years, the high frequency of fungal infections originating from Candida and dermatophyte strains has accelerated treatment attempts. Antimicrobial susceptibility test for poly insert ignore into journalissuearticles values(AN-co-VP); / copolymer, which we think could be an ideal drug in treatment interventions was evaluated with disk diffusion method and minimum inhibitor concentration. In the antimicrobial measurement data, it was determined that the poly insert ignore into journalissuearticles values(AN-co-VP); / coolymer dissolved in pure water is an significant inhibitory property against the growth of yeast insert ignore into journalissuearticles values(on Candida spp. with 11.33 ± 0.3 mm barrier area); and dermatophyte fungi insert ignore into journalissuearticles values(on Epidermophyton sp. and Trichophyton sp. with 12.33 ± 0.3 mm barrier area); insert ignore into journalissuearticles values(p<0.001); and no inhibitory properties were observed in preventing the growth of all bacteria insert ignore into journalissuearticles values(Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae, Staphylococcus aureus, Bacillus megaterium);. MIC limit values that prevent the growth of dermatophytes and yeasts supporting the disc diffusion method are 50-100 μL. This study is an alternative approach in order to limit the spread of superficial fungal infections they cause and eliminate these infections that tend to be come chronic, since this polymer extract has no inhibitory properties on bacteria but prevents the growth of yeast and dermatophytes.
Keywords : copolymer, antifungal, alternative approach, inhibitory property