Preparation and Investigation of Antibacterial Activities of Ciprofloxacin Imprinted p(HEMAH) Cryogels

Authors : Neslihan İDİL, Sevgi ASLIYÜCE ÇOBAN, Adil DENİZLİ

Pages : 55-64

Doi:10.15671/hjbc.915115

View : 21 | Download : 10

Publication Date : 2022-01-05

Article Type : Research Paper

Abstract :Staphylococcus aureus, Enterococcus faecalis and Escherichia coli are the common causes of wound infections. For the treatment of these infections, ciprofloxacin can be recommended as a broad-spectrum antibiotic that acts on both Gram-negative and Gram-positive microorganisms. Besides, antimicrobial agents could be integrated into polymeric materials. Cryogels, one of these polymeric materials, are spongy polymers showing high macroporosity. In addition to their attractive usage as affinity support materials and scaffolds, they also appear as drug carrier materials in recent years. Molecular imprinting method is a recognition technique prepared by forming a polymeric network around the template. Although this method has been used in purification and separation processes for more than thirty years, it has gained great interest as a new approach that provides an advantage in drug release studies in terms of high drug loading capacity and long-term release. In this study, ciprofloxacin insert ignore into journalissuearticles values(CIP); imprinted 2-Hydroxyethyl methacrylate insert ignore into journalissuearticles values(HEMA); based N-methacryloyl-insert ignore into journalissuearticles values(L);-histidine methyl ester insert ignore into journalissuearticles values(MAH); containing [CIP-pinsert ignore into journalissuearticles values(HEMAH);] cryogels was prepared and characterized. CIP releasing experiments were performed, and then, antimicrobial activities of CIP pinsert ignore into journalissuearticles values(HEMAH); cryogels were examined against S. aureus, E. faecalis and E. coli. It can be concluded that CIP-pinsert ignore into journalissuearticles values(HEMAH); cryogels could be proposed as promising polymeric materials for wound healing applications.
Keywords : Ciprofloxacin, Molecular imprinting, Cryogels, Antimicrobial activity