Neuroprotective Effects of Dexmedetomidine in Acute Carbon Monoxide Intoxication: An Experimental Study

Authors : Hüseyin Büyükkeskin, Güvenç Doğan, Selçuk Kayır, Ercan Ayaz, Yasin Kenesarı, Alperen Kısa, Sibel Önen Özdemir, Özgür Yağan

Pages : 20-28

Doi:10.52827/hititmedj.1485232

View : 25 | Download : 18

Publication Date : 2025-02-25

Article Type : Research Paper

Abstract :Objective: It is aimed to evaluate the neuroprotective effects of Dexmedetomidine (DEX), which has antioxidant, antiapoptotic, anti-inflammatory properties, in acute carbon monoxide toxicity. Material and Method: 28 Wistar-Albino female rats were randomly divided into four groups as control, Carbon monoxide (CO) poisoning, CO poisoning + DEX and DEX only. The rats in the study groups were exposed to 3000 ppm CO for 30 minutes. DEX was administered half an hour after the onset of CO exposure. At the end of the experiment, blood and tissue samples were taken from the sacrificed rats. Bcl-2 Immunopositively cell values in tissue samples taken from prefrontal and hippocampal areas were scored by examining immune expressions of Bcl-2 antibodies obtained by immunohistochemical method under light microscope. Malondialdehyde (MDA), nitric oxide (NO), asymmetric dimethylarginine ADMA levels, superoxide dismutase (SOD), and catalase (CAT) activity values were measured from blood and right hemisphere brain tissue samples by biochemical methods. Results: CAT, SOD, MDA, ADMA and NO values were statistically different between the experimental groups (p 0.05). CAT, SOD and NO, and Bcl-2 immunosuppressive cell levels were decreased in the CO group compared to the control group (p<0.001 in all), while ADMA and MDA levels increased (p<0.001 in all). CAT, SOD, and NO levels were statistically higher in the CO + DEX group compared to the CO group (p:0.007; p:0.028; p:0.017, respectively). Conclusion: DEX administered half an hour after CO poisoning increases antioxidant structures such as CAT, SOD and NO. Accordingly, DEX may have a neuroprotective effect for carbon monoxide poisoning.
Keywords : Deksmedetomidin, Karbonmonoksit, Nöroprotektif etki

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