Investigation of Antibacterial and Cytotoxic Properties of Mix Ligand Complex of Zinc 2-Fluorobenzoate with Nicotinamide

Authors : Giray Bugra AKBABA, Cem OZTURK

Pages : 269-274

Doi:10.17350/HJSE19030000157

View : 22 | Download : 12

Publication Date : 2019-12-31

Article Type : Research Paper

Abstract :I n this study, antibacterial properties of the previously synthesized zinc 2-fluorobenzoate with nicotinamide complex at 1.17; 2.33; 4.67; 9.34 and 18.67 mM concentrations was investigated using by agar well diffusion method against Bacillus subtilis, Psedomonasa eruginosa, Staphylococcus aureus, Escherichia coli, Bacillus cereus and Klebsiella pneumoniae bacterias. The MTT method was used to determine the cytotoxic properties of the complex on human peripheral blood cells at the same concentrations. According to the results of the antibacterial study, it was determined that the complex showed a good antibacterial effect on all bacteria at 18.67 and 9.34 mM concentrations. The complex exhibits to have a suppressive effect only on S. aureus bacteria at a concentration of 2.33 mM. It was observed that the complex was antibacterial on all bacteria except B. cereus and E. coli at a concentration of 4.67 mM. The complex was found to have no growth inhibiting effect on any bacteria at a concentration of 1.17 mM. The cytotoxicity of the complex was investigated by MTT test method and it was determined that the cell viability decreased due to increasing concentration according to the test results. Cell viability at 1.17; 2.33; 4.67; 9.34 and 18.67 mM was determined to be 86.20%, 86.05%, 72.87%, 64.77% and 6.42%, respectively
Keywords : Zinc complexes, Antibacterial activity, MTT, Cytotoxicity, Antibiotics