The Structure-Activity Relatıonships of Familiar Antiepileptic Drugs and Na+ Channels

Authors : Esra Nur ÇAKMAK, Mahmut GÜR, Bayram KIRAN
Pages : 89-102
Doi:10.17350/HJSE19030000259
View : 35 | Download : 6
Publication Date : 2022-06-30
Article Type : Research Paper
Abstract :The aim of this study is to examine the effects of drug active compounds, which are widely used in the treatment of epilepsy, on voltage-gated Na+ channels are important channels that advance the action potential in the excitation direction by molecular docking method. These molecules have been selected considering the physiopathological effect mechanisms of epilepsy disease. When the action potential is stimulated, Na+ channels allow sodium ion entry into the cell and cause epilepsy seizures. For this reason, PDB ID: 4PA6 receptor, which acts as an antagonist according to its activity on the canal in the formation of epileptic seizures, was chosen for molecular docking study. As a result of molecular docking studies; Phenytoin gave the best binding affinity for 4PA6 with a value of -7.7 kcal/mol. Other results in descending order insert ignore into journalissuearticles values(as kcal/mol);; Mesuximide insert ignore into journalissuearticles values(-7.5);, Remasemide insert ignore into journalissuearticles values(-7.3);, Tiagabine insert ignore into journalissuearticles values(-7.1);, Ethotoin and Mephenytoin insert ignore into journalissuearticles values(-7.0);, Primidon insert ignore into journalissuearticles values(-6.9);, Topiramate insert ignore into journalissuearticles values(-6.6);, Oxcarbazepine and Lamotrigin insert ignore into journalissuearticles values(-6.3);, Felbamat insert ignore into journalissuearticles values(-6.0);, Lokosamidine insert ignore into journalissuearticles values(-5.9);, Zonisamide insert ignore into journalissuearticles values(-5.8);, Levetiresetam and Gabapentin insert ignore into journalissuearticles values(-5.7);, Ethosuximide insert ignore into journalissuearticles values(-5.6);, Trimethadion insert ignore into journalissuearticles values(-5.1);, Valproic Acid insert ignore into journalissuearticles values(-5.0);, Vigabatrin insert ignore into journalissuearticles values(-4.0);, determined as.
Keywords : Anticonvulsant, Epilepsy, Moleculer Docking, Ligand, Receptor

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