EVALUATION OF OTOTOXICITY IN GENTAMICIN TREATED MODERATELY AND LATE PREMATURE INFANTS

Authors : Berfin Uysal, Saime Ceylan, Hakan Erdoğan

Pages : 185-196

View : 51 | Download : 45

Publication Date : 2023-12-24

Article Type : Research Paper

Abstract :The objective of our research is to investigate the prevalence of ototoxicity throughout the early stages of infancy in middle and late preterm infants who were hospitalized and treated with gentamicin in the Neonatal Intensive Care Unit (NICU). Our study focused on premature babies admitted to the Neonatal Intensive Care Unit of our hospital between 1 May 2015 and 30 April 2016, in their middle and late stages. Patients were divided into two groups as receiving and not receiving gentamicin treatment. One patient from each group were unable to succeed the initial auditory brainstem response (ABR) assessment. There was no discernible distinction between the two groups. It was determined that 8 patients failed the TEOAE test. Four of these patients were assigned to the group receiving gentamicin, whereas four were assigned to the control group. These 8 patients were directed to the Ear Nose and Throat Clinic for examination. Otitis media was diagnosed in six cases and treatment was initiated, whereas the evaluation of two patients yielded unremarkable results. Following the therapies, the second auditory brainstem response (ABR) test was conducted once more on these eight individuals. Each patient exceeded this test. Upon evaluation, no auditory impairment is detected. There was no documented occurrence of gentamicin-induced damage to the auditory system (ototoxicity). We think that neonatal intensive care patients who are exposed to ototoxic agents such as gentamicin and other hearing loss risk factors and long-term follow-up of especially premature ones are important in this respect. Considering factors such as duration of use and dose, we observed that gentamicin-induced ototoxicity did not develop in our study group.
Keywords : Gentamisin, ototoksisite, tedavi