THE RELATIONSHIP OF VITAMIN D LEVEL IN CORD BLOOD WITH INDIRECT HYPERBILIRUBINEMIA

Authors : Kamile Merve Bircan, Dilek Sarici

Pages : 661-684

View : 31 | Download : 76

Publication Date : 2025-12-24

Article Type : Research Paper

Abstract :Introduction and Aim: Studies on cord blood vitamin D levels in term babies with indirect hyperbilirubinemia are very limited. According to our knowledge, there is no study on this subject in preterm babies. The aim of our study is to determine whether there is a relationship between vitamin D level in cord blood and indirect hyperbilirubinemia. Materials and methods: It was conducted with 78 newborns and 76 mothers who were born in our hospital between March 1, 2020 and July 1, 2020. The mothers\\\' age, delivery type, gravida and parity, dressing style, BMİ just before birth, prenatal vitamin D supplementation status, and the interval between two births were recorded. Gender, gestational week, anthropometric measurements and feeding patterns of the newborns were recorded. Blood was taken from the cord blood of all babies at birth for 25 (OH) Vitamin D level. Babies were evaluated according to nomograms determined by transcutaneous bilirubin. While newborns below the limit were included in the healthy group, serum total bilirubin, direct bilirubin, hemoglobin, hematocrit, leukocyte and platelet levels were studied from the newborns with jaundice above the limit. Results: Twenty (52.6%) of term babies were healthy and 18 (47.4%) were included in the patient group. 16 of preterm babies (40%) were classified as patients and 24 (60%) as healthy. In our study, the mean value of vitamin D in the cord blood of babies was 11.6 ± 6.87 ng / mL in the term patient group and 14.66 ± 9.51 ng / mL in the term healthy group. The mean cord blood vitamin D of preterm babies was 13.53 ± 8.31 ng / mL in the patient group and 13.95 ± 8.33 ng / mL in the healthy group. However, there was no significant difference in vitamin D between term- preterm patients and healthy groups (p = 0.269, p = 0.876). The mean BMI of the mothers was 31.62 ± 1.63 kg / m2 in the term patient group, 28.26 ± 2.15 kg / m2 in the term healthy group, 32.01 ± 2.34 kg / m2 in the preterm patient group, in the preterm healthy group was 27.43 ± 2.75 kg / m2 and a significant difference was found between their groups (p <0.001). Conclusion: A clinically significant but not statistically significant difference was found between cord blood vitamin D levels of babies with term jaundice and healthy babies. In addition, it was found that maternal BMI of term and preterm babies with indirect hyperbilirubinemia was higher than healthy babies.
Keywords : Kord kanı D vitamini, Serum total bilirubin, Maternal obezite, Antropometrik ölçümler, Vücut kitle indeksi

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