VASCULAR ARTERY SIMULATION MODEL FABRICATION FOR PRE-SURGERY KIT FOR STENT APPLICATION THROUGH 3D PRINTING

Authors : Tuğba UĞURTAŞ, Hakan YILMAZER

Pages : 268-276

Doi:10.46519/ij3dptdi.1246758

View : 40 | Download : 28

Publication Date : 2023-08-31

Article Type : Other Papers

Abstract :Thrombosis occurs of a blood clot in the vein and blocking blood flow. The formation of a clot within the artery is called arterial thrombosis. Due to arterial thrombosis, there are heart attacks and strokes that result in more than 17.9 million deaths worldwide each year. Covid-19, one of today\`s problems, further increases the mortality rate. The thrombosis mechanism includes factors coming from the blood and the vessel wall. This mechanism is based on local blood flow mechanisms and 3-dimensional insert ignore into journalissuearticles values(3D); vessel geometry. Microfluidics chip-based vascular models examine the interaction between blood and the vessel wall in vitro studies in thrombosis. Until now, the 3-dimensional geometry of the arteries and blood flow system of healthy or unhealthy individuals have not been fully modeled. In this study, a patient-specific occluded blood vessel model was obtained from computed tomography angiography insert ignore into journalissuearticles values(CTA); data, and miniature vascular structures were developed with a 3D printer. These structures were printed using Acrylonitrile Butadiene Styrene insert ignore into journalissuearticles values(ABS);. 3D ABS samples were used in Polydimethylsiloxane insert ignore into journalissuearticles values(PDMS); based soft lithography molds to occur microfluidic systems containing miniaturized replicas of in vivo vessel geometries. A comprehensive simulation of stented vasculature was performed by flow analysis of artificial blood and cell culture by placing a commercial stent on PDMS-based models. This project has aimed to develop and characterize modules by creating microfluidic systems using 3D printers to examine the effects of stents placed in the patient\`s complex vascular system and to simulate operations before treatment and stent placement.
Keywords : ABS, PDMS, STENT, 3D printing, Microfluidics, Patient specific modelling, Mikroakışkanlar, Hastaya özel modelleme