Determination of spectrophotometric protonation constant of cholinesterase inhibitors

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International Journal of Chemistry and Technology
Volume:1 Issue:1
Determination of spectrophotometric protonation constant of cholinesterase inhibitors

Determination of spectrophotometric protonation constant of cholinesterase inhibitors

Authors : Yaşar Doğan DALDAL, Ebru ÇUBUK DEMİRALAY, Güleren ALSANCAK

Pages : 7-13

Doi:10.32571/ijct.335934

View : 41 | Download : 11

Publication Date : 2017-10-17

Article Type : Research Paper

Abstract :T he protonation constant insert ignore into journalissuearticles values(pK a ); of rivastigmine, galantamine and donepezil which are cholinesterase inhibitors used in cure of Alzheimer`s disease in acetonitrile-water binary mixtures were determined at 25 o C in ionic strength by spectrophotometric method. Spectra of the drugs were recorded with 1 nm resolution over the 200 to 400 nm interval. Data assessment was carried out with the STAR software program to calculate molar absorbances and stability constants of the compounds studied. A queous protonation constant of these compounds were calculated from determined through linear relationship between the mole fraction of acetonitrile and the pK a v alues and the Yasuda-Shedlovsky equality. The pK a values of inhibitors at 25°C were converted to values at 37°C, without extra estimation. The predicted and calculated pK a values were compared with literature values.
Keywords : Cholinesterase Inhibitors, Protonation Constant, UV VIS Spectrophotometry, Solute Descriptors

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