Synthesis and biological activities of new hybrid chalcones with benzoic acid ring

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International Journal of Chemistry and Technology
Volume:6 Issue:1
Synthesis and biological activities of new hybrid chalcones with benzoic acid ring

Synthesis and biological activities of new hybrid chalcones with benzoic acid ring

Authors : Bedriye Seda KURŞUN AKTAR, Yusuf SICAK, Emine Elçin ORUÇEMRE

Pages : 7-14

Doi:10.32571/ijct.1003871

View : 97 | Download : 22

Publication Date : 2022-07-06

Article Type : Research Paper

Abstract :A series of E-4-insert ignore into journalissuearticles values(3-oxo-3-insert ignore into journalissuearticles values(substituted);prop-1-en-1-yl);benzoic acid derivatives insert ignore into journalissuearticles values(1-5); were synthesized by the Claisen-Schmidt condensation of various ketones with 4-formylbenzoic acid. The anticholinesterase insert ignore into journalissuearticles values(AChE and BChE);, tyrosinase, and urease inhibition activities of the synthesized compounds insert ignore into journalissuearticles values(1-5); were examined. It was found that the most active compound against AChE enzyme in anticholinesterase inhibition activity was compound 1. Compound 4 was the most active compound in tyrosinase inhibition activity, while compound 3 was the most active compound in urease psychological activity.
Keywords : Chalcone, Anticholinesterase activity, Tyrosinase inhibitory activity, Urease inhibitory activity

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