Evaluation of the genotoxic effect of nonylphenol applied in different doses on the bone marrow

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International Journal of Chemistry and Technology
Volume:7 Issue:1
Evaluation of the genotoxic effect of nonylphenol applied in different doses on the bone marrow

Evaluation of the genotoxic effect of nonylphenol applied in different doses on the bone marrow

Authors : Nazmiye BİTGEN, Özge GÖKTEPE, Münevver BARAN, Eren Kaan İPEK, Arzu YAY

Pages : 108-112

Doi:10.32571/ijct.1186924

View : 107 | Download : 45

Publication Date : 2023-06-30

Article Type : Research Paper

Abstract :Nonylphenols are endocrine disrupting toxic compounds and are widely used. For this reason, our study aimed to investigate the genotoxic effect of nonylphenols applied at different doses on mouse bone marrow cells. Groups were classified as control group, the sham administered only group, low dose, medium dose and high dose nonylphenol administered group. After euthanasia, polychromatic erythrocyte/Normochromatic erythrocyte ratio and micronuclear polychromatic erythrocyte count were determined in femur bone marrow cells and analyzed to detect DNA damage. While polychromatic erythrocyte/Normochromatic erythrocyte ratio was found to be lower in the groups treated with different doses of nonylphenol, especially in the group treated with high-dose nonylphenol, this decrease was not statistically significant. When the micronucleated polychromatic erythrocyte values were examined, it was observed that there was a statistically significant increase, especially in the medium and high dose groups compared to the control. High-dose nonylphenol has a toxic effect and may have a long-term genotoxic effect such as cancer development by interacting with genotoxic agents.
Keywords : Nonylphenol, genotoxicity, micronucleus

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