CORRELATION OF GATA-3, E-CADHERIN, P53 AND KI-67 EXPRESSION WITH HISTOLOGICAL TYPE/MOLECULAR SUBTYPE AND CLINICOPATHOLOGICAL PARAMETERS IN BREAST CANCER

Authors : Yeliz ARMAN KARAKAYA, Sevda YILMAZ

Pages : 105-116

Doi:10.33457/ijhsrp.875887

View : 28 | Download : 10

Publication Date : 2021-04-28

Article Type : Research Paper

Abstract :Aims The purpose of our study is to examine immunohistochemically the correlation of GATA binding protein 3 insert ignore into journalissuearticles values(GATA3);, E-cadherin, p53 and Ki-67 expression with histological type/molecular subtype and clinicopathological parameters in breast cancer. Methods and results 120 patients diagnosed with breast cancer were retrospectively investigated between 2018 May and 2021 January. We used the GATA3, E-cadherin, P53, Ki67 antibody by immunohistochemical analysis in breast tumors. GATA3 was positive in 100% insert ignore into journalissuearticles values(107/107); of the luminal A, luminal B and HER2 overexpressing groups and 79.9% insert ignore into journalissuearticles values(10/13); of the triple negative insert ignore into journalissuearticles values(TN); group. It is less common in the TN group insert ignore into journalissuearticles values(p 20% was higher in human epidermal growth factor receptor 2 insert ignore into journalissuearticles values(HER2); overexpressing and TN groups compared to luminal A and luminal B subtypes insert ignore into journalissuearticles values(p 0.05);. Conclusions Our study demonstrated that the presence of GATA3 was found to be associated with the ER/PR receptor and tumors associated with these receptors, lumen type breast carcinomas. In addition to its proper use for diagnostic purposes in routine surgical pathology, GATA3 will have a developmental role in breast carcinomas and prognostic significance in different molecular subtypes of tumors at the same clinical stage. Ki67 is observed at a higher rate in high-grade tumors and has a prognostic significance. No significant correlation was reported between e-cadherin and p53 and prognostic factors.
Keywords : breast cancer, molecular classification, GATA3, p53, Ki67, e cadherin