Low temperature calorimetry of 3-fluoro-5-(3-pyridinyloxy) benzenamine and N-[3-fluoro-5-(3-pyridinyloxy)phenyl]-N’-3-pyridinyl urea

Authors : Rongchun Lİ, Keyan SUN, Yushan HUA, Zhicheng TAN, Quan SHİ

Pages : 153-157

Doi:10.5541/eoguijt.292047

View : 43 | Download : 8

Publication Date : 2017-09-01

Article Type : Other Papers

Abstract :The investigation on thermodynamic properties of drug intermediates plays a crucial role in the design and synthesis of new drugs as well as understanding their biological activities in vivo. In this work, the thermodynamic properties of two drug intermediates of 3-fluoro-5-insert ignore into journalissuearticles values(3-pyridinyloxy); benzenamine and N-[3-fluoro-5-insert ignore into journalissuearticles values(3-pyridinyloxy);phenyl]-N’-3-pyridinyl urea were studied by means of low temperature calorimety performed in a Physical Property Measurement System calorimeter. The heat capacities of these two compounds were measured over the temperature region from insert ignore into journalissuearticles values(1.9 to 300); K, and the corresponding thermodynamic functions were consequently calculated on the basis of the heat capacity curve fitting. Additionally, a group additivity method were employed for estimating the heat capacity values of these two compounds at 298.15 K, which are in good agreement with the values measured in this work.
Keywords : 3 fluoro 5 3 pyridinyloxy, benzenamine, N, 3 fluoro 5 3 pyridinyloxy, phenyl, N 3 pyridinyl urea, Low temperature calorimetry, Heat capacity

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