Protective Effects of Selenopyran Against Carbon Tetrachloride Hepatotoxicity in Rats

Authors : L B ZAVODNIK, D B VOLOSHIN, A SKOMOROSHKO, T N BUDKO1, V İ KONDAKOV, R N LIAKH1, A M KHOKHA, B PALECZ

Pages : 26-0

Doi:10.21448/ijsm.240713

View : 19 | Download : 10

Publication Date : 2014-07-14

Article Type : Research Paper

Abstract :Carbon tetrachloride insert ignore into journalissuearticles values(CCl4); is a known hepatotoxic compound working through the generation of reactive free radicals. Selenium insert ignore into journalissuearticles values(Se); is an essential trace element required by animals and humans for protection against xenobiotic compounds. In this study, Se, as selenopyran, has been evaluated for its protective action against CCl4-induced hepatotoxicity in Wistar rats. CCl4 exerts its toxic effects by generation of free radicals; it was intraperitoneally administered to male Wistar rats insert ignore into journalissuearticles values(2g/kg body weight); 24 h before the animals were decapitated. Selenopyran insert ignore into journalissuearticles values(2mg/kg body weight); was administered intragastrically one month before CCl4 injection. Rats injected with CCl4 alone showed significant lipid and hydropic dystrophy of liver, massive necrosis of hepatocytes, increases in free and conjugated bilirubin levels were marked as well as elevation of hepatic enzymes insert ignore into journalissuearticles values(alanine aminotransferase and aspartate aminotransferase); in plasma. Selenopyran administered at a pharmacological dose diminished the toxic effects of CCl4. Thus it decreased both the structural and functional injury of hepatocytes and clearly exerted hepatoprotective effects. These findings suggest that the effect of selenopyran on CCl4-induced acute liver injury depends on the antioxidant action Se.
Keywords : selenopyran, сarbon tetrachloride, free radical, hepatotoxicity, rats