Chemistry of Secondary Metabolites (Production, Properties, Biological Activity, etc.): Solubility Study of the Interaction between Pamam G-3 Dendrimer and 5 Fluorouracil in Aqueous Solution

Authors : B PALECZ, A BUCZKOWSKI, L B ZAVODNIK

Pages : 3-0

Doi:10.21448/ijsm.240715

View : 24 | Download : 8

Publication Date : 2014-07-14

Article Type : Research Paper

Abstract :Polyinsert ignore into journalissuearticles values(amidoamine); dendrimers insert ignore into journalissuearticles values(PAMAM); are polymeric macromolecules that can find their use as carriers of small ligand molecules such as cosmetics and drugs. 5- Fluorouracil is a potent oncological drug, whose usage is limited because of its relatively high toxicity.The surface and internal layer groups in PAMAM dendrimer belonging to the third insert ignore into journalissuearticles values(G3); generation create an open-type structure, which facilitate small ligand molecules to bind with them.The formation equilibrium of PAMAM G3 dendrimer complex with an oncologic drug such as 5 fluorouracil insert ignore into journalissuearticles values(FU); in water at room temperature was examined. Using the results of the drug solubility in dendrimer solutions, the maximal number of drug molecules in the dendrimer-drug complex was evaluated. Solubility results show that PAMAM G3 dendrimer can transfer tens 5 fluorouracil molecules in aqueous solution.This research work was funded from the Polish budget appropriations for science in the years 2013-2015, project number IP2012 022372.
Keywords : poly amidoamine, dendrimers, 5 fluorouracil, Metabolites