Analysis of phytochemical composition and biological activities of Helichrysum pallasii (Sprengel) ledeb leaves

Authors : Nejmi IŞIK, Muzaffer MÜKEMRE, Rabia Sena TÜRKER, Gokhan ZENGİN, Abdullah DALAR

Pages : 71-85

Doi:10.21448/ijsm.1132698

View : 13 | Download : 6

Publication Date : 2023-03-26

Article Type : Research Paper

Abstract :This study aimed at the investigation of in vitro biological activities insert ignore into journalissuearticles values(antioxidant and enzyme inhibition); and phytochemical composition of various extracts insert ignore into journalissuearticles values(ethanol maceration, aqueous infusion, and aqueous decoction); obtained from leaf organs of Helichrysum pallasii, which has been traditionally used as herbal tea and medicine in Eastern Anatolia. Experimental analysis showed that ethanol-based extract had higher total phenolic content insert ignore into journalissuearticles values(TPC: 103 mg GAE/gE); and showed superior antioxidant potentials insert ignore into journalissuearticles values(FRAP: 2205 μmol Fe2+/gE; ORAC: 2540 μmol Trolox Eq./gE; DPPH: IC50=0.58 mg/ml; CUPRAC: IC50=0.37 mg/ml; Phosphomolybdenum: IC50=1.34 mg/ml ve metal chelation: IC50=1.42 mg/ml); and enzyme inhibition insert ignore into journalissuearticles values(Acetylcholinesterase: IC50=1.49 mg/ml; Butyrylcholinesterase: IC50=1.98 mg/ml; Tyrosinase: IC50=0.68 mg/ml; Alpha-amylase: IC50=2.09 mg/ml; Alpha-glucosidase: IC50=0.51 mg/ml; and Pancreatic lipase: IC50=42.5 μg/ml); and contained higher amounts of phenolic insert ignore into journalissuearticles values(chlorogenic acid isomers and rutin); and fatty acid insert ignore into journalissuearticles values(palmitic, linoleic, and linolenic acids); compounds than traditional preparations insert ignore into journalissuearticles values(infusion and decoction);. The current study\`s findings indicate that the leaves of the Helichrysum pallasii are a source of phytochemicals with strong antioxidant and enzyme inhibitory properties, implying that it could be a candidate for biotherapeutic agent research and development.
Keywords : Helichrysum pallasii, Antioxidant, Enzyme inhibition, Phenolics, Biotherapeutic