Antimicrobial evaluation of the Patchouli (Pogostemon cablin Benth.) leaf essential oil combination with standard antimicrobial compounds

Authors : Nazlı Şenay BEŞİRİK, Gamze GÖGER

Pages : 385-393

Doi:10.21448/ijsm.1232606

View : 74 | Download : 66

Publication Date : 2023-08-27

Article Type : Research Paper

Abstract :Pogostemon cablin Benth\`s leaves, which belong to the Lamiaceae family, are used to make patchouli essential oil insert ignore into journalissuearticles values(PEO);. Sesquiterpenes are the main compounds in essential oil. Antibacterial, antifungal, antiviral, antiemetic, and anti-inflammatory activities are just a few of the many pharmacological actions that are well-known. In this investigation, cefuroxime insert ignore into journalissuearticles values(CEF);, moxifloxacin insert ignore into journalissuearticles values(MOX);, clarithromycin insert ignore into journalissuearticles values(CLA);, fluconazole insert ignore into journalissuearticles values(FLU);, and terbinafine insert ignore into journalissuearticles values(TER); were combined with patchouli insert ignore into journalissuearticles values(Pogostemon cablin leaf essential oil);. Gram-positive Staphylococcus aureus ATCC 6538, Gram-negative Escherichia coli ATCC 8739, and yeasts Candida albicans ATCC 10231, and C. tropicalis ATCC 750 were tested against all combinations. Drug interaction was given as fractional inhibitory concentrations insert ignore into journalissuearticles values(FIC); after combinations of the essential oils were tested for their minimum inhibitory concentrations insert ignore into journalissuearticles values(MIC);. The checkerboard method was used to assess antimicrobial interactions, Fluconazole, terbinafine, cefuroxime, and clarithromycin combined with essential oil demonstrated an \`additive effect\` against Candida strains together with E. coli and S. aureus.
Keywords : Pogostemon cablin, essential oil, checkerboard method, antibacterial, antifungal