Investigation of the Acute Subacute Toxicity of KL-21® Supplementary Food Product in Rats

Authors : Mustafa YAŞAR, Güliz SARAÇ, Ali GÖK, Nisa SİPAHİ, Aydan Fülden AĞAN
Pages : 190-196
Doi:10.53811/ijtcmr.1121162
View : 44 | Download : 8
Publication Date : 2022-12-15
Article Type : Research Paper
Abstract :Objective: KL21®; It is a food supplement using remember regeneration therapy method insert ignore into journalissuearticles values(RTM);. KL21®. Whereas products that containing combined medicinal plants are expected to be beneficial for health, on the other hand, their toxic properties are able to potentially increase due to the interactions of the active ingredients in the plants. With this study, it was aimed to investigate the toxic effect of KL21®. Material-Method: In the study conducted with control insert ignore into journalissuearticles values(n: 8);, acute insert ignore into journalissuearticles values(n: 8);, subacute insert ignore into journalissuearticles values(n: 8); and post-subacute insert ignore into journalissuearticles values(n: 8); groups; the daily dose of the product was tested by gavage in 8-week-old female Wistar rats. Biochemical parameters P, Ca, ALB, TG, TP, TC, Creatinine, Bilirubin, GGT, ALP, AST and ALT were analyzed. In hematological parameters; WBC, RBC, PLT, HCT, HGB were examined. Liver, lung, spleen, kidney and heart tissues were investigated histopathologicaly. Clinical observation was made throughout the entire process. Results: When the acute, subacute and post-subacute groups were compared to control, it was observed that there was no significant difference in biochemical, hematological, histopathological terms. No toxicity-related side effects were found in clinical observations. Conclusion: The potential toxic effect of daily use dose of KL21® containing the combined medicinal plant was investigated in vivo. According to the hemogram, biochemistry and pathology tests, it was determined that it does not show acute and subacute toxicity.
Keywords : KL 21®, Food supplement, Acute, Subacute, Post subacute toxicity

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