Chemometric Determination of Valsartan in The Presence of Its Carboxylic Acid-Induced Triiodide Ion Product by Spectrophotometric Method

Authors : Fatma DEMİRKAYA MİLOĞLU, Elmas POLATDEMİR, Yücel KADIOĞLU

Pages : 82-90

View : 14 | Download : 8

Publication Date : 2022-10-14

Article Type : Review Paper

Abstract :A new spectrophotometric method optimized with central composite design insert ignore into journalissuearticles values(CCD); for quantitative estimation of valsartan insert ignore into journalissuearticles values(VL); in pharmaceutical preparations was developed. The developed method is based on the oxidation of VL with potassium iodate insert ignore into journalissuearticles values(KIO3); to form a carboxylic acid derivative. In the presence of the -COOH group, iodide insert ignore into journalissuearticles values(KI); is oxidized by iodate, leading to the formation of a yellow-colored triiodide ion with an absorption maximum at 352 nm. The CCD, one of the chemometric methods were applied for the determination of the experimental conditions and then Kinetic studies were used for the stability period. The equilibration time was determined as 10 min. The volumes of 0.05 M KI and 0.003 M KIO3 were calculated as 1.92 mL insert ignore into journalissuearticles values(0.0192 M); and 2.96 mL insert ignore into journalissuearticles values(0.000177 M);, respectively, and the temperature was measured as 27°C. The method was linear in the concentration range of 6-34 µg/mL insert ignore into journalissuearticles values(R2: 0.996);. The LOD and LOQ were obtained as 0.81 and 2.46 µg/mL, respectively. The pharmaceutical dosage forms were analyzed with developed method, and the obtained results ranged from 98.3% to 102.9%. The developed method was a simple, rapid and inexpensive method for routine analysis of VL in pharmaceutical dosage form
Keywords : Valsartan, Central composite design, UV Vis Spectrophotometry