Synthesis and antimicrobial evaluation of some new hydrazone derivatives of 6-(4-nitrophenyl)imidazo[2,1-b]thiazole-3-acetic acid hydrazide

Authors : Nuray Ulusoy Güzeldemirci1, DİLEK ŞATANA2, ÖMER KÜÇÜKBASMACI3

Pages : 127-138

View : 44 | Download : 12

Publication Date : 2016-11-22

Article Type : Research Paper

Abstract :Abstract: In this study, some novel N2-arylidene/cycloalkylidene-insert ignore into journalissuearticles values(6-insert ignore into journalissuearticles values(4-nitrophenyl);imidazo[2,1-b]thiazol-3-yl);acetic acid hydrazides insert ignore into journalissuearticles values(2a-d); were synthesized from insert ignore into journalissuearticles values(6-insert ignore into journalissuearticles values(4-nitrophenyl);imidazo[2,1-b]thiazol-3-yl);acetic acid hydrazide insert ignore into journalissuearticles values(1);. The newly synthesized compounds were characterized by IR, 1H NMR, mass and elemental analysis. Their antibacterial and antifungal activities were evaluated against S. aureus ATCC 29213, P. aeruginosa ATCC 27853, E. coli ATCC 25922, C. albicans ATCC 10231, C. parapsilosis ATCC 22019, C. krusei ATCC 6258, T. mentagrophytes var. erinacei NCPF 375, M. gypseum NCPF 580 and T. tonsurans NCPF 245. N2-Cyclohexylidene-insert ignore into journalissuearticles values(6-insert ignore into journalissuearticles values(4-nitrophenyl);imidazo[2,1-b]thiazol-3-yl);acetic acid hydrazide insert ignore into journalissuearticles values(2c); and N2-insert ignore into journalissuearticles values(3-methylcyclohexylidene);-insert ignore into journalissuearticles values(6-insert ignore into journalissuearticles values(4-nitrophenyl);imidazo[2,1-b]thiazol-3-yl);acetic acid hydrazide insert ignore into journalissuearticles values(2d); showed the highest antibacterial activity. Particularly 2c showed the highest antifungal activity against tested fungi. Key words: Imidazo[2,1-b]thiazole, arylidene/cycloalkylidenehydrazides, antibacterial activity, antifungal activity
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