Association between Β3-Adrenergic receptor (ADRB3) gene polymorphism with body mass index and bone mineral density in Turkish postmenopausal women

Authors : Özlem Kurtşirin1, Hülya Yılmazaydoğan2 Mehmet Uyar3, Mehmet Fatih Seyhan2, TURGAY İŞBİR2, AYŞE CAN1

Pages : 7-18

View : 36 | Download : 9

Publication Date : 2016-11-26

Article Type : Research Paper

Abstract :Abstract: Previous studies have suggested that β3-adrenergic receptor insert ignore into journalissuearticles values(ADRB3); gene is associated with body mass index insert ignore into journalissuearticles values(BMI);, which is an important predictor of bone mineral density insert ignore into journalissuearticles values(BMD);. However, little is known concerning the effect of the ADRB3 gene on BMD. The present study investigated the relationship between ADRB3 Trp64Arg polymorphism, BMI and BMD in Turkish postmenopausal women. 133 postmenopausal women insert ignore into journalissuearticles values(81 osteoporotic and 52 healthy control); were recruited. For the detection of ADRB3 Trp64Arg polymorphism, polymerase chain reaction-restriction fragment lenght polymorphism insert ignore into journalissuearticles values(PCR-RFLP); techniques have been used. BMD was measured at the lumbar spine and hip by dual-energy X-ray absorptiometry. Distribution of ADRB3 Trp64Arg genotypes was similar in the study groups insert ignore into journalissuearticles values(p>0.05);. “Arg/Arg” genotype was not observed. In the osteoporotic group, subjects with “Trp/Trp” genotype tended to have lower BMI values compared to those with “Trp/Arg” genotype, the difference was closely tied to statistical significance insert ignore into journalissuearticles values(p=0.052);. Subjects with “Trp/Trp” genotype had also lower BMD values of femoral neck insert ignore into journalissuearticles values(p=0.044); and total hip insert ignore into journalissuearticles values(p=0.043); than those with “Trp/Arg” genotype. No significant effects of the ADRB3 Trp64Arg genotypes on BMI and BMD values were found in the control group. Our results suggested that ADRB3 Trp64Arg “Trp/Trp” genotype might be associated with osteoporosis risk by affecting body mass index and bone mineral density values in Turkish postmenopausal women. Key words: β3-adrenergic receptor, gene polymorphism, body mass index, bone mineral density, postmenopausal women
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