The effects of endocrine disrupting chemicals and genetic susceptibility on male infertility

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İstanbul Journal of Pharmacy
Volume:45 Issue:1
The effects of endocrine disrupting chemicals and genetic susceptibility on male infertility

The effects of endocrine disrupting chemicals and genetic susceptibility on male infertility

Authors : Merve Arıcı GÜL ÖZHAN

Pages : 39-60

View : 33 | Download : 13

Publication Date : 2016-11-26

Article Type : Research Paper

Abstract :Abstract: Reproductive functions in men are impaired by many environmental, physiologic, and genetic factors. Xenobiotics insert ignore into journalissuearticles values(e.g. phthalate, alkylphenols, heavy metals, bisphenol A, ets); are the majority of the environmental factors which happen adverse effects with covalent interactions between intermediate metabolites and cellular macromolecules. The recent publications regarding infertility have stated that the substances do not only interfere human’s normal hormone functions, but also cause the reproductive disorders such as testicular germ line cancer and prostate hyperplasia. The xenobiotics disrupting endocrine system are metabolized by the enzyme involved phase I insert ignore into journalissuearticles values(e.g., CYP450); and II insert ignore into journalissuearticles values(e.g., NAT, SULT); enzymes. Most of the enzymes are polymorphic and genetic variants modify the enzyme catalytic activities. Thus, the effects of endocrine disrupting chemicals might vary between individuals. To date, the impact of genetic variability in the capacity of metabolizing xenobiotics has not been extensively studied on male reproductive functions. The relation between environmental and genetic factors and infertility has not been shown clearly. Therefore, we aimed to evaluate the interaction between endocrine disruptors’ exposure and polymorphisms involved in genes insert ignore into journalissuearticles values(e.g., DAZL, MTHFR, POLG); in male infertility risk by data obtained from previously studies. Key words: Polymorphism, endocrine disruptors, reproduction, testis, fertility
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