Cytotoxicity and genotoxicity of fenoxaprop-p-ethyl and fluzifob-p-butyl herbicides

Authors : Bahar ULUS, Müzeyyen ÇELİKSÖZ, Gül ÖZHAN

Pages : 5-8

Doi:10.5152/IstanbulJPharm.2017.002

View : 44 | Download : 10

Publication Date : 2017-10-10

Article Type : Research Paper

Abstract :Human populations are exposed to several toxic substances in the environment, including pesticides. Fenoxaprop-p-ethyl insert ignore into journalissuearticles values(FPE); and fluzifob-p-butyl insert ignore into journalissuearticles values(FPB); herbicides are extensively used in agricultural fields due to their high target selectivity and low non-target toxicity. They are known as aryloxyphenoxypropionate herbicides, and acetyl-CoA carboxylase inhibitor. In the study, we aimed to evaluate the toxic potentials of FPE and FPB herbicides. Cell viability was evaluated by MTT assay in the range of 15.6-500.0 μM exposure concentrations in mouse fibroblast insert ignore into journalissuearticles values(BALB/3T3); cell line. Also, we investigated their DNA damage potentials on BALB/3T3 cells by using alkaline Comet assay. The results indicated that FPE and FPB showed no evidence of DNA damage. And, the cell viability was more than 20% at 12.5-400 μM exposure concentrations. FPE and FPB might be safe according to our results and the previously studies, and there would be public health benefits from encouraging its use in the place of more toxic herbicide products.
Keywords : Fenoxaprop p ethyl, fluzifob p butyl, 3T3 cells

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