Anticancer activities and cell death mechanisms of 1H-indole-2,3-dione 3-[N-(4 sulfamoylphenyl)thiosemicarbazone] derivatives

Authors : İdil ÇETİN, Pınar ERASLAN ELMA, Mehmet TOPÇUL, Nilgün KARALI

Pages : 63-67

View : 31 | Download : 11

Publication Date : 2018-12-01

Article Type : Research Paper

Abstract :DOI: 10.26650/IstanbulJPharm.2018.414805 In this study, the cytotoxic effects of 1H-indole-2,3-dione 3-[N-insert ignore into journalissuearticles values(4-sulfamoylphenyl);thiosemicarbazone derivatives namely, 4a-d were evaluated using cell kinetic parameters including the cell index, mitotic index, labelling index and apoptotic index on HeLa cells taken from a human cervix carcinoma. All compounds were evaluated using cell index parameters at 5, 10, 20, 40, 80, 100 and 160 μM concentrations. As a result of this, it was seen that all 4a-d compounds were effective in different concentrations. Different cell death mechanisms were proposed for 4a-d. When all the parameters were examined, it was found that the bromine substituted 4c was the most potent antiproliferative compound in the tested compounds. The difference was significant between the control and experimental groups insert ignore into journalissuearticles values(p<0.01);. In addition, a statistically significant difference was noted among all experimental groups insert ignore into journalissuearticles values(p<0.01);.
Keywords : 1H indole 2, 3 dione, thiosemicarbazone, antiproliferative effect, HeLa cells

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