Effects of common variations of NOS3 and CAV1 genes on hypercholesterolemic profile in coronary heart disease

Authors : Serap İLİKAY, Ender COŞKUNPINAR, Özlem KURNAZGÖMLEKSİZ, Zehra BUĞRA, Allison P ERONAT, Oğuz ÖZTÜRK, Hülya YILMAZAYDOĞAN

Pages : 53-60

View : 42 | Download : 11

Publication Date : 2019-08-01

Article Type : Research Paper

Abstract :DOI : 10.26650/IstanbulJPharm.2019.18010 Caveolin-1 insert ignore into journalissuearticles values(CAV-1); plays a crucial role in endothelial-nitric oxide synthase insert ignore into journalissuearticles values(eNOS); enzymatic activity. Therefore, CAV-1 and eNOS interactions have a significant impact on endothelial dysfunction, cholesterol levels, and atherosclerosis. We investigated the critical variations in NOS3 and CAV1 genes in this case–control study to determine the relations between the coronary heart disease insert ignore into journalissuearticles values(CHD); risk factors. The NOS3-rs1799983, CAV-1 rs3840634, and rs3807990 variations were analyzed in 76 CHD patients and 91 controls using the polymerase chain reaction. Mean serum Total-cholesterol levels were significantly higher in CHD patients with the CAV-1 rs3807990-T allele than in patients with CC genotype insert ignore into journalissuearticles values(p=0.017);. There was a statistically significant correlation between the rs3807990-T allele and hypercholesterolemia in the CHD group insert ignore into journalissuearticles values(p=0.008);. The multivariate analysis confirmed that the CAV-1 rs3807990-T allele insert ignore into journalissuearticles values(p=0.011); is a risk factor for hypercholesterolemia. Moreover, the serum HDL-Cholesterol level was detected to be higher in patients carrying both CAV1-rs3807990-T and NOS3-rs1799983-T alleles than those with the CAV-1 rs3807990-CC/NOS3-rs1799983-GG genotype subgroup insert ignore into journalissuearticles values(p=0.013);. These results suggested that the genetic variations of CAV-1 rs3807990 and NOS3-rs1799983 may contribute to the increased hypercholesterolemia risk and thus on the development of CHD. Cite this article as : İlikay S, Coşkunpınar E, Kurnaz-Gömleksiz Ö, Buğra Z, Eronat AP, Öztürk O, Yılmaz-Aydoğan H insert ignore into journalissuearticles values(2019);. Effects of common variations of NOS3 and CAV1 genes on hypercholesterolemic profile in coronary heart disease. Istanbul J Pharm 49 insert ignore into journalissuearticles values(2);: 53-60.
Keywords : Cav1, NOS3, gene, hypercholesterolemia, lipid, CHD

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