In vitro investigation of Sorbus domestica as an enzyme inhibitor

Authors : Gozde HASBAL, Tugba YILMAZ OZDEN, Musa SEN, Refiye YANARDAG, Ayse CAN

Pages : 28-32

View : 48 | Download : 11

Publication Date : 2020-04-01

Article Type : Research Paper

Abstract :Background and Aims: Finding new therapeutic enzyme inhibitors by investigating especially medicinal plants is an important research area. The fruits and leaves of Sorbus domestica insert ignore into journalissuearticles values(service tree); are used as food and folk remedies due to astringent, antidiabetic, diuretic, antiinflammatory, antiatherogenic, antidiarrhoeal, vasoprotective, and vasorelaxant activities, and also used commercially as a vitamin and antioxidant. In this study, the therapeutic effect of S. domestica against diabetes, Alzheimer’s disease, aging, and hyperuricemia was investigated. Methods: α-Glucosidase, α-amylase, acetylcholinesterase insert ignore into journalissuearticles values(AChE);, butyrylcholinesterase insert ignore into journalissuearticles values(BChE);, elastase and xanthine oxidase insert ignore into journalissuearticles values(XO); inhibitory activities of the fruit extract from S. domestica were measured. Results: The extract showed inhibitory activity against α-glucosidase, α-amylase, BChE, elastase, and XO whereas AChE inhibitory activity of the extract could not be determined. Moreover, the inhibition effects of the extract against α-glucosidase and elastase were more effective than the standard drugs acarbose and ursolic acid, respectively. Conclusion: S. domestica can be evaluated as a potential source for a new therapeutic agent.
Keywords : α glucosidase, α amylase, acetylcholinesterase, butyrylcholinesterase, elastase, xanthine oxidase

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