Spectrophotometric determinations of most commonly used statins in pharmaceutical preparations with 2,3-dichloro-5,6-dicyanobenzoquinone

Authors : Gamze ERGİN KIZILÇAY, Sıdıka ERTÜRK TOKER

Pages : 95-102

View : 102 | Download : 8

Publication Date : 2020-08-27

Article Type : Research Paper

Abstract :Background and Aims: In this study, simple, accurate and precise spectrophotometric methods were developed for the determination of five 3-hydroxy-3-methylglutaryl-coenzyme-A insert ignore into journalissuearticles values(HMG-CoA); reductase inhibitors in pure and pharmaceutical dosage forms. Methods: In the developed methods, atorvastatin fluvastatin, pitavastatin, rosuvastatin and simvastatin were used in this class of drugs called statins. The methods were based on the charge-transfer reaction of n-electron donor drugs with π-acceptor 2,3-dichloro-5,6-dicyano-1,4-benzoquinone insert ignore into journalissuearticles values(DDQ);. All variables such as temperature, time, reaction medium, amount of reagent were examined for optimal formation of complexes to be given by the drugs with DDQ and optimal conditions were determined. Results: The linearity ranges for atorvastatin, fluvastatin, pitavastatin, rosuvastatin and simvastatin were found to be 0.5-50, 1-6, 2.5-50, 5-25 and 5-50 μg/mL, respectively. Conclusion: The proposed methods were successfully applied to both the pure and the pharmaceutical dosage forms
Keywords : HMG CoA reductase inhibitors, spectrophotometric determination, charge transfer reaction, DDQ, pharmaceutical preparations

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