- İstanbul Journal of Pharmacy
- Volume:5
- Antihistaminik Madde İhtiva Eden İlaçların Kantitatif İnce Tabaka Kromatografisi
Antihistaminik Madde İhtiva Eden İlaçların Kantitatif İnce Tabaka Kromatografisi
Authors : Serpil Demir, Hayriye ã‚mal
Pages : 80-90
View : 34 | Download : 10
Publication Date : 2013-06-25
Article Type : Research Paper
Abstract :The wide-spread use of antihistaminic preparations has resulted, in the development of analytical techniques for the identification and assay of these compounds. Macek and Vacerkovatl); used paper and thin-layer chromatography, Gendi et al. insert ignore into journalissuearticles values(2);, Fike and Sunshine C3); used thin-layer chromatographic technique for the identification of antihistamines. As the usual color reactions for detection of the antihistamine spots are based on the reactions of amine group or intracyclic nit-rogene, Dragendorf f reagent insert ignore into journalissuearticles values(4);, p-dimethylaminobenzaldehyde insert ignore into journalissuearticles values(4);, eerie sulfate insert ignore into journalissuearticles values(5);, Pauly reagent, potassium iodoplatinate, ammonium vanadate-sulfuric acid were used for this purpose. Different methods were proposed for the quantitative determination of antihistamines. The United States Pharmacopeia insert ignore into journalissuearticles values(6); and the British Pharmacopoeia insert ignore into journalissuearticles values(7); utilize nonaqueous titrimetric or ultraviolet spectrophotometric methods. Blaug and Zopfinsert ignore into journalissuearticles values(8); proposed an ion exchange separation for the determination of diphenhydramine HC1, doxylamine HC1, chlorpheniramine maleate and tripellenamine HC1, alone or in pharmaceutical preparations. Morrison and Chatteni5); proposed a quantitative thin-layer technique which is based on the careful measurement of spot area from which the concentration of the substance can be calculated. This paper deals with the identification by TLC and estimation by quantitative thin-layer technique of the below mentioned antihistamines in solution or in multicomponent pharmaceuticals.Keywords :
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