ALLELIC VARIANTS AT ALCOHOL METABOLISING GENES IN TURKISH POPULATION

Authors : B ALPERTUNGA, E S YILDIZ, G ÖZHAN, B Alpertunga, E S Yildiz, G Özhan B ALPERTUNGA, E S YILDIZ, G ÖZHAN

Pages : 113-122

View : 40 | Download : 12

Publication Date : 2014-01-10

Article Type : Conference Paper

Abstract :Alcohol dehydrogenase insert ignore into journalissuearticles values(ADH); and aldehyde dehydrogenase insert ignore into journalissuearticles values(ALDH); play central roles in the initial stages of alcohol metabolism. Polymorphisms with physiological significance exist in the ADH and ALDH genes to different degrees in different ethnic groups. Specifically, ADH1B*2 insert ignore into journalissuearticles values(ADH1B*47His);, ADH1B*3 insert ignore into journalissuearticles values(ADH1B*369His);, ADH1C*1 insert ignore into journalissuearticles values(ADH1C*349Ile); and ALDH2*2 insert ignore into journalissuearticles values(ALDH2*487Lys); variants have been shown to confer protection against alcohol toxicity and dependence. During the past decade, the prevalence of alcoholism in Turkey has significantly increased with the economic development and industrialization of the country. Thus, the aim of this study was to investigate genetic differences in polymorphisms of alcohol-metabolizing enzymes, ADH1B, ADH1C and ALDH2, for Turkish population by using polymerase chain reaction insert ignore into journalissuearticles values(PCR);-restriction fragment length polymorphism insert ignore into journalissuearticles values(RFLP); method. Also, the frequencies of alleles were compared with those obtained from different populations. In conclusion; the allelic frequencies for ADH1B*2, ADH1B*3, ADH1C*1 and ALDH2*2 were observed 0.049, 0.004, 0.397 and 0.018, respectively. Turkish people resemble Caucasians while being different from Asians in terms of the distribution of ADH1B*2, ADH1C*1, ALDH2*2 alleles. Furthermore, Turkish people have less ADH1B*3 allele than the other populations, especially African-Americans. 
Keywords : ADH, ALDH, Turkish population, Genotype frequency

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