DRUG RELEASE FROM PEG SUPPOSITORY BASES AND FROM THEIR COMBINATION WITH POLYMERS

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İstanbul Journal of Pharmacy
Volume:33
DRUG RELEASE FROM PEG SUPPOSITORY BASES AND FROM THEIR COMBINATION WITH POLYMERS

DRUG RELEASE FROM PEG SUPPOSITORY BASES AND FROM THEIR COMBINATION WITH POLYMERS

Authors : 1 M Akhtar, 2 N Akhtar, 3 M Ahmad 4 AS ARIF, 5 PERVAIZ A SHAH

Pages : 7-16

View : 31 | Download : 12

Publication Date : 2015-09-08

Article Type : Research Paper

Abstract :In vitro investigation was conducted to evaluate the drug insert ignore into journalissuearticles values(Metronidazole); release from the formulation containing \`PEG SUPPOSITORIES BASES\` and its combination with CMC and PVP. The experiments were conducted at various temperatures and at rectal pH. When the percentage of the dmg release was upto 65%, the rate of release vs time was linear but with combinations insert ignore into journalissuearticles values(with PVP and CMC); the rate was only linear upto 50% drug release at 37 °C. Linear relationship was also observed between average molecular weight of the bases upto 50% release rate at temperatures 37 °C, 40 °C, and 45 °C. Different drug release was not only dependant on the average molecular weight but also the proportions of various PEG bases. Key words: Ethylene glycol, Diethylene glycol, Tragacanth, Metronidazole, Suppository bases.
Keywords : Ethylene glycol, Diethylene glycol, Tragacanth, Metronidazole, Suppository bases

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