The effects of vanadyl sulfate on glutathione, lipid peroxidation and nonenzymatic glycosylation levels in various tissues in experimental diabetes

Authors : Sevim TUNALI, Refiye YANARDAĞ
Pages : 73-78
View : 30 | Download : 7
Publication Date : 2021-04-30
Article Type : Research Paper
Abstract :Background and Aims: Diabetes mellitus is characterized by hyperglycemia which over time leads to serious damage of several body systems. Vanadium ions and their complexes have been demonstrated to have various insulin-mimetic and antidiabetic effects. The object of the present work was to investigate the effect of vanadyl sulfate insert ignore into journalissuearticles values(VS); on serum total lipid and protein parameters, glutathione, lipid peroxidation and nonenzymatic glycosylation levels in cardiac, lens, lung and skeletal muscle tissues of STZ diabetic rats. Methods: Randomly selected 6.0 - 6.5 month old Swiss Albino rats were separated into two diabetic and two control groups. A single intraperitoneal injection of 65 mg/kg streptozotocin insert ignore into journalissuearticles values(STZ); in 0.01 M citrate buffer insert ignore into journalissuearticles values(pH 4.5); was used to induce diabetes. 100 mg/kg VS was administered daily to one of the controls and one of the diabetic groups. On the 60th day of the experiment, serum total lipid and total protein levels were determined. Results: Tissue samples were taken and used for determination of glutathione insert ignore into journalissuearticles values(GSH);, lipid peroxidation insert ignore into journalissuearticles values(LPO); and nonenzymatic glycosylation insert ignore into journalissuearticles values(GSH); and protein levels. Conclusion: According to the results, treatment with VS reversed the effects of diabetes by exerting antioxidant properties and preventing damage caused by diabetes on various tissues along with some serum parameters.
Keywords : Diabetes mellitus, vanadyl sulfate, oxidative stress, cardiac, lens, lung, skeletal muscle

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