Central possible antinociceptive mechanism of naringin

Authors : Mehmet Evren OKUR, Çinel KÖKSAL KARAYILDIRIM

Pages : 204-211

View : 45 | Download : 16

Publication Date : 2021-08-31

Article Type : Research Paper

Abstract :Background and Aims: The object of this study was the investigation of the central antinociceptive effects of naringin as well as the association of stimulation of opioidergic, serotonergic, adrenergic, and cholinergic insert ignore into journalissuearticles values(muscarinic and nicotinic); receptors to the central analgesia of mice due to naringin. Methods: Several intraperitoneal doses insert ignore into journalissuearticles values(20, 40, and 80 mg/kg); were injected into mice models and analyzed via hot-plate insert ignore into journalissuearticles values(integrated supraspinal response); and tail-immersion insert ignore into journalissuearticles values(spinal reflex); for the possible antinociceptive effects of naringin. Moreover, the involved action mechanism was investigated using 80 mg/kg naringin insert ignore into journalissuearticles values(i.p.); administered to the mice which were previously pre-treated with opioid antagonist naloxone insert ignore into journalissuearticles values(5 mg/kg, i.p.);, serotonin 5-HT2A/2C receptor antagonist ketanserin insert ignore into journalissuearticles values(1 mg/kg, i.p.);, α2-adrenoceptor antagonist yohimbine insert ignore into journalissuearticles values(1 mg/kg, i.p.); and muscarinic antagonist atropine insert ignore into journalissuearticles values(5 mg/kg, i.p.);, as well as nicotinic antagonist mecamylamine insert ignore into journalissuearticles values(1 mg/kg, i.p.);. Results: It can be claimed that a dose-dependant antinociceptive effect of naringin was noticed for 40 and 80 mg/kg doses in tail-immersion and hot-plate tests, respectively. Furthermore, the improvement of inactivity of naringin-induced response to thermal stimuli was counteracted by mecamylamine and naloxone when tested with the tail-immersion test, and hot-plate analyses. Conclusion: From the data, it was confirmed that naringin presents central antinociceptive effects which may be coordinated by supraspinal/spinal mediated opioidergic and nicotinic insert ignore into journalissuearticles values(cholinergic); inflection. Nevertheless, it is unclear how naringin organizes the interactions of the aforementioned modulatory systems. To conclude, naringin could be a possible candidate for pain relief management.
Keywords : Antinociception, opioidergic receptors, nicotinic antagonist, pain, central mechanisms, naringin

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