Anti-fertility and antisteroidogenic activity of Clerodendrum serratum in mature male rats

Authors : Navaneetha Krishnan SUBRAMANİYAN, Nagarajan Govinda RAJAN, Karthikeyan ELUMALAİ, Sathyanathan VİSWANATHAN, Jayaraman RAJANGAM, Preeti GUTHA, Sivaneswari SRİNİVASAN

Pages : 212-220

View : 58 | Download : 9

Publication Date : 2021-08-31

Article Type : Research Paper

Abstract :Background and Aims: The study was designed to evaluate the anti-fertility effect of methanolic extract of Clerodendrum serratum insert ignore into journalissuearticles values(MECS); on mature male rats. Methods: The vehicles and MECS were administered orally to four groups of forty male albino rats on consecutive days for 30 days. At the end of the experimental period, five animals from both the control and experimental groups were given anesthesia and the animal reproductive organs were collected and anti-fertility effect evaluated by studying the following parameters insert ignore into journalissuearticles values(i); Body and reproductive organ weight insert ignore into journalissuearticles values(ii); Biochemical estimation insert ignore into journalissuearticles values(iii); Reproductive hormone analysis insert ignore into journalissuearticles values(iv); Abnormalities in reproductive organ histology. Another five rats in each group were subjected to fertility testing. Results: This study shows that female rats which mated with MECS treated male rats delivered fewer pups than those which mated with the control rats. An antisteroidogenic effect was revealed through the increased concentration of testicular cholesterol and ascorbic acid in MECS treated rats. However, testicular Δ 5-3β-hydroxysteroid dehydrogenase insert ignore into journalissuearticles values(Δ5-3β-HSD);, glucose-6-phosphate dehydrogenase insert ignore into journalissuearticles values(G-6-PD);; serum reproductive hormones testosterone, FSH and LH were significantly reduced. Conclusion: The present investigation discovered the antisteroidogenic effect of MECS, which confirms the male antifertility effect of this plant. This encourages the traditional use of this plant in the Indian subcontinent as a male contraceptive.
Keywords : Clerodendrum serratum, Δ5 3β hydroxysteroid dehydrogenase Δ5 3β HSD, glucose 6 phosphate dehydrogenase G 6 PD, reproductive hormones

ORIGINAL ARTICLE URL