Study of in vitro antiinflammatory and immunomodulatory effect of Ayurvedic plants – Murva

Authors : Aparna ANN MATHEW, Raju ASİRVATHAM, A GOWTHAM, Daisy PA
Pages : 333-340
Doi:10.26650/IstanbulJPharm.2021.877929
View : 54 | Download : 11
Publication Date : 2021-12-29
Article Type : Research Paper
Abstract :Background and Aims: Toxic chemicals, pathogens and damaged cells trigger the inflammatory process and cause disease in the kidney, heart, brain, liver, lung and reproductive system. The present study evaluates the anti-inflammatory and immunomodulatory effect of Ayurvedic plants under the Murva category. Methods: Marsdenia tenacissima is an acceptable source of Murva. Sansevieria roxburghiana is considered as Murva in west Bengal. Methanol extracts of both plants were used to evaluate anti-inflammatory and immunomodulatory effects by certain in vitro methods. The in vitro anti-inflammatory effects of methanol extract Marsdenia tenacissima insert ignore into journalissuearticles values(MEMT); and methanol extract of Sansevieria roxburghiana insert ignore into journalissuearticles values(MESR); were assessed by heat and hypotonic induced haemolysis on the red blood cells of rats. Nitro blue tetrazolium insert ignore into journalissuearticles values(NBT); assay and inhibition of TNF-α release in DAL cell lines were conducted to assess the immunomodulatory potential of extracts. Results: MEMT, MESR and a combination of MEMT&MESR showed significant insert ignore into journalissuearticles values(p<0.001); inhibition of haemolysis on heat and hypotonic induced methods compared with the standard Diclofenac Sodium. In NBT reduction test, MEMT showed a more significant insert ignore into journalissuearticles values(p<0.001); result than MESR. Similarly, the inhibition of TNF-α release was also significantly enhanced by 400 μg/ mL of MEMT. Conclusion: The present research results revealed that Murva is a safe Ayurveda drug for the treatment of cancer and cardiac disease with the protection of systemic immunity and set free from an inflammatory condition.
Keywords : Murva, Marsdenia tenacissima, Sansevieria roxburghiana, in vitro anti inflammatory, immunomodulatory, NBT assay

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