Diapin®: A food supplement with diverse therapeutic potentials

Authors : Umar Faruk MAGAJİ, Selahattin BOYACI, Umut BULBUL, Sadettin AKÇA, Özlem SAÇAN, Refiye YANARDAĞ

Pages : 302-310

Doi:10.26650/IstanbulJPharm.2022.980682

View : 62 | Download : 11

Publication Date : 2022-12-30

Article Type : Research Paper

Abstract :Background and Aims: For many centuries herbs and spices have traditionally been used to treat or manage a variety of dis- eases. The formulation of food supplements containing single or multiple herbs or spices is now popular. These formulations provide biochemical, pharmacological and medicinal benefits due to their diverse phytochemical constituents. Methods: In the present study, Diapin® – a food supplement containing Olea europaea L. leaves extract, Cinnamomum cassia insert ignore into journalissuearticles values(L.); J. Presl stem extract, Nigella sativa L. seed oil, Cocos nucifera L. oil and vitamin D3 – dissolved in absolute ethanol was evaluated for α-amylase, α-glucosidase, acetylcholinesterase, elastase, neuraminidase, adenosine deaminase and arginase inhibitory activity. Results: The supplement strongly inhibited neuraminidase insert ignore into journalissuearticles values(IC50 = 0.272 ± 0.007 mg/mL);, while adenosine deaminase, ace- tylcholinesterase, elastase and arginase were moderately inhibited insert ignore into journalissuearticles values(with an IC50 of 4.562 ± 0.052, 5.396 ± 0.563, 5.783 ± 0.058 and 6.800 ± 0.067 mg/mL respectively);. The less inhibition activity was on α-amylase and α-glucosidase insert ignore into journalissuearticles values(IC50 = 9.593 ± 0.582 and 14.010 ± 2.280 mg/mL respectively);. Conclusion: The pharmacological activities of Diapin® can be attributed to its opulent phytochemical composition. The pres- ent findings support the folkloric claim of Diapin® supplement having antidiabetic, anticancer, anti-inflammatory, antimicro- bial, anti-ageing, and immune bolstering properties, in addition to the mitigation of Alzheimer’s disease and the alleviation of neurological dysfunction.
Keywords : Diapin®, Olea europaea, Cinnamomum cassia, Nigella sativa, Cocos nucifera, enzyme inhibition, extracts

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