Thermosensitive in situ gel formulation and characterization studies of Sambucus ebulus L. extract

Authors : Umay Merve GÜVEN, Yusuf YAKUT, Nurdan ÇAKIR, Serpil DEMİRCİ KAYIRAN

Pages : 30-38

View : 53 | Download : 131

Publication Date : 2023-04-28

Article Type : Research Paper

Abstract :Background and Aims: Sambucus ebulus L. has been used to treat inflammation-related gastrointestinal disorders, influen- za, kidney ailments, lung diseases, rheumatoid arthritis, and snake and insect bites. Our study provides important ethnobo- tanical information about S. ebulus with the aim of developing a formulation with increased extract bioavailability, diminished side effects, and easy drug loading and dose adjustment as an effective local therapy for dermatologic diseases. Methods: Twelve in-situ gels with S. ebulus were prepared as antifungal treatments in accordance with the cold method and formulated using poloxamer and hydroxypropyl methylcellulose insert ignore into journalissuearticles values(HPMC);. The formulations were characterized in terms of pH, gelling capacity, swelling degree, spreadability, and rheological properties. Results: Among the prepared in situ gel formulations, the Poloxamer 407 and 407-HPMC mixtures of P14H1 and P15 demon- strated acceptable gelation temperatures for dermal use. Conclusion: Thermosensitive in-situ gels containing S. ebulus may be a viable alternative for treating fungal diseases.
Keywords : Sambucus ebulus L, in situ gel, gelling system, topical antifungal

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