EFFECT OF PROPOLIS ON WOUND HEALING: A CLINICAL AND HISTOMORPHOMETRIC STUDY IN RATS

Authors : Aysun AKPINAR, Hakan ÖZDEMİR

Pages : 81-88

Doi:10.34084/bshr.1289441

View : 59 | Download : 62

Publication Date : 2023-08-30

Article Type : Research Paper

Abstract :Background: Propolis is known to have antioxidant, antiinflammatory, antibacterial, antiviral, immunostimulant and local anesthetic effects. The aim of the present study was to investigate the clinical and histomorphometric effects of propolis on the healing of excisional palatal wounds in rats. Materials and methods: Sixty male Wistar rats were used for the study. Six animals were sacrificed at beginning of the study as initial wound insert ignore into journalissuearticles values(0 day);. The rats were divided into three groups: Propolis insert ignore into journalissuearticles values(P);, Chlorhexidine insert ignore into journalissuearticles values(CHX); and Control insert ignore into journalissuearticles values(C);. Subjects in all three groups were randomly selected to form nine subgroups of six rats each. Under anesthesia, circular excision wounds with a diameter of 3 mm were formed in the middle of the palate of the rats by punching. The mucoperiosteal part was removed with sharp dissection, and the area on the open bone surface was left to heal the secondary wound. Propolis was administered locally at a rate of 1 ml/day. The rats were sacrificed on days 7, 14, and 21, and pictures of the wound area were taken. Each photograph was transferred to a dedicated program to measure the defect area. Histological sections were taken and the presence of inflammatory cells, epithelialization, and degree of healing were assessed. Results: The average wound area between epithelial margins decreased significantly over time in all groups insert ignore into journalissuearticles values(p <0.05);. compared to CHX and C groups, significant reduction of wound area was observed after seven, 14 and 21 days by using Propolis at insert ignore into journalissuearticles values(respectively 5.56±3.77; 3.70±1.76; 1.12±0.83); On day 21st day, the inflammatory cells were still observed in the Control group. Conclusion: The results of the study show that Propolis has a positive effect on the healing of soft tissue by accelerating wound healing.
Keywords : Propolis, klorheksidin glukonat, yara iyileşmesi