EBER In Situ Hybridization Experience In Hodgkin Lymphoma

Authors : Gulen GUL, Mehmet Ali ÖZCAN, Sermin ÖZKAL

Pages : 201-204

Doi:10.30621/jbachs.985629

View : 20 | Download : 8

Publication Date : 2021-09-20

Article Type : Research Paper

Abstract :Purpose Several studies suggest that the relation of Epstein-Barr virus insert ignore into journalissuearticles values(EBV); and Hodgkin lymphoma insert ignore into journalissuearticles values(HL);. EBV and HL associations are reported at rates ranging from 20% to 100% that varies nationally and regionally. In this study; in the case of Hodgkin`s lymphoma, the presence of EBV encoded RNA insert ignore into journalissuearticles values(EBER); by in situ hybridization method and it’s distribution according to histopathological subtypes were investigated. Methods We investigated the presence of EBV in Hodgkin Lymphoma diagnosed 107 adult cases between 2013 and 2017, which chromogenic in situ hybridization with EBV RNA probe has been in routine use were evaluated retrospectively with pathology reports. Results There were 69 males and 38. Nodular Sclerosis Classical Hodgkin Lymphoma insert ignore into journalissuearticles values(NSCHL); was the most common insert ignore into journalissuearticles values(63 cases, 58,9%); followed by Mixed Cellularity Classical Hodgkin Lymphoma insert ignore into journalissuearticles values(MCCHL); insert ignore into journalissuearticles values(23 cases,21,5%);. EBV was expressed in 40 cases insert ignore into journalissuearticles values(45,4%);. High EBV association was found with NSCHL insert ignore into journalissuearticles values(50%); and MCCHL insert ignore into journalissuearticles values(48%);. None of NLPHL was positive with EBER. Conclusion In our series NSCHL is the most common histologic subtype and has higher percentages of EBV positivity as reported in developed countries. Our study has the largest series of patients investigating the relationship between HL and EBER in our country. For further comments more studies, particularly from Turkey, are needed to determine the actual epidemiological pattern of HL in the region and to define the role of EBV in HL.
Keywords : EBER, EBV, Hodgkin Lymphoma