Evaluation of the Effect of the Combination of Boron Compounds on Chronic Liver Disease

Authors : Özgür ÇELEBİ, Demet ÇELEBİ, Ali TAGHİZADEHGHALEHJOUGHİ, Sümeyye BAŞER, Mustafa Can GÜLER, Serkan YILDIRIM

Pages : 163-169

Doi:10.16899/jcm.1176975

View : 20 | Download : 18

Publication Date : 2023-03-22

Article Type : Research Paper

Abstract :Aim: Enterococcus faecalis has surface adhesion proteins that enable it to attach to human intestinal and vaginal tissue cells with antibiotic-resistant strains in patients. Due to these properties, boron and its derivatives are preferred as therapeutic agents due to their antibacterial, antifungal, antiparasitic and antifungal activities. In this study, we aimed to evaluate the synergistic effect of boron compounds and their effect on biofilms in an infection model created with Enterococcus faecalis 29212 on the HepG2 liver cell line. Materials and Methods: It was determined that sodium perborate monohydrate + zinc borate had the lowest values as a result of the minimum inhibitory concentration and fractional inhibitor concentration studies. It has also been shown that these doses reduce cytotoxic effects. In addition, 32 µg/ml Etidote + 256 µg/ml Sodium Perborate Monohydrate showed the highest biofilm effect. Results: we show that boron compounds effectively reduce biofilm formation and cause the death of bacteria.
Keywords : Biyofilm, Bor Bileşikleri, Fraksiyonel İnhibisyon Konsantrasyonu, Hücre Kültürü, Sinerjik Etki, Biyofilm, Bor Bileşikleri, Fraksiyonel İnhibisyon Konsantrasyonu, Hücre Kültürü, Sinerjik Etki