Subthalamic Nucleus Degeneration As A Dark Cause of Parkinson’s Disease Due to Subarachnoid Hemorrhage: A Preliminary Experimental Study

Authors : Mete ZEYNAL, Mehmet Hakan ŞAHİN

Pages : 215-220

Doi:10.16899/jcm.1239008

View : 19 | Download : 13

Publication Date : 2023-03-22

Article Type : Research Paper

Abstract :Background: Although the subtahalamic nucleus degeneration has been accused of Parkinson’s disease, the obscure roles of subtalamic nucleus degeneration induced by subarachnoid hemorrhages has not been adequately studied. The aim of the study is to examine the histopathological changes in the subthalamic nucleus after subarachnoid hemorrhage. Materials and Methods: Twenty-one wild male healthy rabbits were included in this study. The test subjects were divided as: control insert ignore into journalissuearticles values(GI, n=5);; SHAM 1.2 cc of saline injected insert ignore into journalissuearticles values(GII, n=6); and 1.2 cc of autologous blood injection into cisterna magna insert ignore into journalissuearticles values(GIII, n=10);. They followed up for three weeks and sacrificed under general anesthesia. Vasospasm index insert ignore into journalissuearticles values(VSI); was estimated by the circle surface estimation method, degenerated neuron densities of the subthalamic nucleus were estimated by Stereological methods and analyzed by Mann Witney U test. Results: Two rabbits dead in the study group were represented by meningeal irritation signs and unconsciousness. Prolonged QT intervals, ST depressions, and low voltage QRSs were noticed in GIII animals. Numerical documents of heart-respiratory rates insert ignore into journalissuearticles values(n/min);, VSI values, and degenerated neuron densities of the subthalamic nucleus insert ignore into journalissuearticles values(n/mm3); as follows: 1.05±0.03/ 219±324/21±4/8±3 in GI; 1.75±0.23/209±14/15±4/16±4 in GII; and 2.03±0.14/175±19/19±5/123±21 GIII. P values between the VSI values and degenerated neuron densities of the subthalamic nucleus were nearly eqund: p<0.005 in GI/GII; p<0.0005 in GII/GIII and p<0.00001 in GI/GIII. Conclusion: Subarachnoid hemorrhage causes spasm of the arteries supplying the subthalamic nucleus, leading to ischemic injury, and hydrocephalus leading to mechanical stress injury.
Keywords : Subarachnoid hemorrhage, Subthalamic nucleus, Parkinsons disease, Neuronal degeneration