Prognostic value of systemic immune-inflammation index in head and neck carcinoma patients undergoing definitive radio(chemo)therapy

Authors : Necla GÜRDAL, Yaren CERAN, Ayse KOTEK SEDEF

Pages : 277-281

Doi:10.16899/jcm.1245595

View : 18 | Download : 10

Publication Date : 2023-03-22

Article Type : Research Paper

Abstract :ABSTRACT Background: The aim of this study is to investigate the prognostic effect of the systemic immune-inflammation index insert ignore into journalissuearticles values(SII); in non-surgically managed head and neck carcinoma patients who underwent definitive radioinsert ignore into journalissuearticles values(chemo);therapy. Methods: Twenty four patients who were all treated with radioinsert ignore into journalissuearticles values(chemo);terapy with curative intent for head and neck cancer insert ignore into journalissuearticles values(HNC); were included in the study. All patients were analyzed in terms of age at diagnosis, gender, body mass index, stage, radiotherapy dose/ fraction, chemotherapy insert ignore into journalissuearticles values(CT);, pre-treatment complete blood count parameters, the pre-treatment systemic immune-inflammation index, local relapse, distant failure, overall survival insert ignore into journalissuearticles values(OS);, and disease-free survival insert ignore into journalissuearticles values(DFS);. Results: SII index was observed to be higher in locally advanced patients than in stage I/II patients insert ignore into journalissuearticles values(p=0.004);. In addition, as a result of the evaluation made with ROC insert ignore into journalissuearticles values(receiver operating characteristic); analysis, it was observed that the SII index had a diagnostic value in predicting locally advanced disease insert ignore into journalissuearticles values(AUC:0.867, 95% CI :0.721-1.00, p=0.002);. DFS and OS rates were 79% and 90% at a median follow-up of 9 months. Conclusions: The systemic immune-inflammation index predicts more advanced disease in non-surgically managed head and neck cancer patients. It can be considered as a biomarker that can contribute to the management of definitive radioinsert ignore into journalissuearticles values(chemo);therapy.
Keywords : Head and neck carcinoma, Radiotherapy, Systemic immune inflammation index