Outcomes of Meningioma Patients Undergoing Stereotactic Radiotherapy

Authors : Ela DELİKGÖZ SOYKUT, Dönay AKSAN, Evrim ŞAVLI, Salih Buğra YILMAZ, Hatice TATAROĞLU

Pages : 426-432

Doi:10.16899/jcm.1256587

View : 63 | Download : 100

Publication Date : 2023-05-31

Article Type : Research Paper

Abstract :Aim: Innovations in radiotherapy have paved the way for alternative approaches for the treatment of meningioma, and in this context, radiosurgery has begun to be used in the treatment of meningioma. This study aimed to examine the clinical results of radiosurgery in the treatment of meningioma and to show whether it achieves the main goals, especially in terms of the possibility of tumor control and the success of preventing progression. Materials and Methods: Primary, residual, and recurrent meningioma treated with stereotactic radiosurgery insert ignore into journalissuearticles values(SRS); and stereotactic radiotherapy insert ignore into journalissuearticles values(SRT); between 2013 and 2020 were evaluated retrospectively. Study endpoints were overall survival insert ignore into journalissuearticles values(OS);, progression free survival insert ignore into journalissuearticles values(PFS);, and local control insert ignore into journalissuearticles values(LC);. Results: 73 patients and 81 lesions were analyzed. The median duration of the follow-up period was 49 months insert ignore into journalissuearticles values(range, 7–138 months);. 5- and 7-y OS and PFS were 87.6%, 78.9%; 82.9% and 82.9%, respectively. The tumor control rate was 94.6%. In univariate analysis, gender insert ignore into journalissuearticles values(p=0.007);, radiosurgery for recurrence insert ignore into journalissuearticles values(p=0.011); and number of lesions insert ignore into journalissuearticles values(p=0.030); were found to be factors affecting OS, and number of lesions insert ignore into journalissuearticles values(p<0.001);, grade insert ignore into journalissuearticles values(p=0.048); and tumor size insert ignore into journalissuearticles values(p=0.047); were found to be factors affecting PFS. Number of lesions insert ignore into journalissuearticles values(p=0.022); was remained prognostic factor for PFS in the multivariate analysis. Conclusion: Since SRS/SRT can provide high tumor control in the management of meningioma, it can be preferred as an alternative treatment method, especially in patients who are diagnosed radiologically, who are not candidates for surgery or who refuse surgical treatment, as well as in cases of residual and recurrence in the post-surgical period.
Keywords : Menengiom, Stereotaktik Radyocerrahi, Stereotaktik Radyoterapi

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